Smart rules are a layer on top of the sequence: they watch opens, clicks and silence and change the focus or copy of the next step accordingly. They run as a dry run by default, showing what they would change, and you decide whether to switch them on.
Under Campaigns open Smart rules. You see how many companies would get different copy today and why (repeated opens, a click, no open). Nothing is sent until you switch the rules on.
Opened 3 times without replying: the next step is a short question or a sample, not another argument. The hesitant do not need persuading, they need an easy way to say yes.
Clicked a link: they are warm. The next step can be a concrete meeting slot or a phone call. Colldly flags them as warm contacts in Contacts too.
No open after two steps: change the subject line (the exception to the "Re:" rule), because the problem is delivery or the subject, not the copy. Or try a different time based on the heatmap.
Enable the rules on one campaign and compare replies per step with the previous week. If the follow-up reply rate rises, extend to the other campaigns.